What is 6-APB?
6-APB (also know is Benzo fury) is a novel empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine, and substituted phenethylamine classes. It is structurally related to entactogens like MDA, MDMA, 5-APB, and 5-MAPB.
It is a serotonin-norepinephrine–dopamine reuptake inhibitor for the norepinephrine transporter (NET), dopamine transporter (DAT), and serotonin transporter (SERT), respectively. In addition, 6 APB is also a releasing agent of them; that is, it is a serotonin-norepinephrine-dopamine releasing agent (SNDRA). Also to actions at the monoamine transporters, 6 APB is a potent full agonist of the serotonin 5-HT2B receptor, with a higher affinity for this target than any other site.
6-APB has a formal name: 1-(1-Benzofuran-6-yl)propan-2-amine. The chemical formula for 6-APB is C11H13NO with a molecular weight of 175.23
Effect & Dosage
6-APB is chemically similar to amphetamines and to ecstasy, so it’s reasonable to assume that they have similar effects to those drugs. Hence, people using 6-APB may experience: Feeling very up, alert, chatty, and energized. Being ‘in tune’ with their surroundings and/or with music and colors feeling more intense. Temporary feelings of love and affection for the people they’re with and for the strangers around them.
The toxicity and long-term health effects of recreational 6-APB use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.
How to use 6-APB and effects
6-APB is often consumed orally, either by swallowing pills, pellets or capsules, wrapping powder in a cigarette paper (bombing) or by mixing in a soft drink. The powder form can be snorted (although reportedly nasal use can be painful).
Users report feelings of excitement, euphoria, empathy, stimulation, and increased energy, with visual and auditory hallucinations. Unpleasant physical side effects can include increased heart rate, blood pressure and body temperature, chest pains and palpitations, difficulty urinating, liver damage, nausea and vomiting, and headaches. Unpleasant mental side effects can include anxiety, paranoia, panic, confusion, poor concentration, and short term memory.
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The effects of Benzo Fury tend to peak within 2-3 hours from an oral dose and then plateau for an average period of 4 hours. Coming down is described by users as gradual but with effects having the potential to last up to 14 hours or more from the initial dose.
After-effects can be felt up to 24 hours or more, during this time users may find it difficult to sleep. Like other stimulants, some users report experiencing low mood or flu-like symptoms and general tiredness/lethargy a day or two after use.
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The chemical formula indicated that the effects of this chemical compound might be very similar to MDMA – the most famous phenethylamine synthesized during the last century.
Its pharmacology can provide that it is a strong potent agonist for the 5-HT2B and 5-HT2C receptor, which could potentially be used as a potential anti-depressant. This thesis is mentioned by the author Irina Majumder from the University of Adelaide. Further, it gives the chemical compound 6-APB the possibility to be used in medical trials as a weight loss supplement – because it is a potent agonist to the 5-HT2C receptor responsible for its appetite suppression.
Please note that 6-APB can be studied only under optimal laboratory conditions and that in vivo research involving live organisms is not allowed. 6-APB research chemicals can be safely stored for up to 2 years at room temperature.
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